Current therapies rarely support in vitiligo repigmentation. According to the previous report, some of the vitiligo patients were having low levels of vitamin B12 and folic acid and they also responded slowly to the therapy of aggressive replacement. By getting encouragement by this report, an uncontrolled and non blinded study of vitamin B12 and oral folic acid supplementation was conducted by the investigators in Sweden in which 100 patients having vitiligo disease.
The age range of the patients were from 9 to 79 years; women were 67 and 64 women out of 67 were having active vitiligo disease. By starting the age range from 1 to 65 years, 1 to 43 years of vitiligo were presented. Tablets of 5 mg of folic acid and 1 mg of vitamin B12 were given to all patients on two times daily basis and patients were instructed to take medicine in this combination for around 3 months or even more. UVB exposure was also encouraged to all patients throughout the year. Folate levels and baseline of vitamin B12 were reported normal in the test of subgroup.
Treatment of all patients was continued to 12 months. In 52 patients fractional repigmentation occurred and it was mostly in those areas which were sun exposed. Best success was predicted in the age less than 26 years, 10 years of less vitiligo duration, 7 to 12 months of vitiligo treatment and UVB exposure’s combination.
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